The Oligonucleotide Synthesis Market.size (volume and value) and Market chain structure published by the insight partners through its high-quality database which is a valuable source of guidance and direction for companies and individual interested in the Market. Major companies with their market volumes and revenues are covered for each of the regions (north america, europe, asia pacific, middle east & africa, south & central america).
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The oligonucleotide synthesis market size is estimated to reach US$ 3,971.72 million by 2027 from US$ 1,584.16 million in 2018; it is estimated to grow at a CAGR of 11.1% during 2019–2027.
Synthesis of short fragments of nucleic acids using genetic engineering and enzyme chemistry is called oligonucleotide synthesis. The technique is useful in existing laboratory practice as it provides rapid and inexpensive access to custom-made oligonucleotides of the desired length and sequence. Oligonucleotides are used from initial research and screening to target validation and drug production. Today, subsequent improvements in oligonucleotide synthesis, amplification, and automation have completely revolutionized biological research.
The oligonucleotide synthesis market growth is attributed to the increasing applications of synthesized oligonucleotides, increasing investments for synthetic biology and technological advancements in genome editing tools. However, the growth of the oligonucleotide synthesis market is restrained by factors such as renewed regulations for biotechnology and lack of skilled professionals in life science industry.
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The global oligonucleotide synthesis market, based on product, is segmented into synthesized oligonucleotides, reagents, and equipment. The synthesized oligonucleotide segment is further sub-divided into primers and probes. The synthesized oligonucleotides segment held the largest share among the product segment in the oligonucleotide synthesis market in 2018 and is also anticipated to follow a similar trend over the forecast period.
Synthetic oligonucleotides are being explored for various applications in therapeutics and diagnostics. Oligonucleotides have the property to cause selective inhibition of gene expression by binding to the target DNA/RNA sequences through mechanisms such as antigene, antisense, and RNA interference. These molecules are also known to bind to the target molecules (aptamers), ranging from small molecules to proteins and are, therefore, preferred on a large scale to treat viral diseases and cancer. In addition to diagnostic and therapeutic purpose, oligonucleotides are used for designing DNA microchips that are used as a powerful bio-analytical tool and novel material in the field of nanotechnology. Owing to the benefits offered by synthesized oligonucleotides, the demand for the segment is expected to grow significantly during the forecast period. In 2020, 10 oligonucleotide drugs have received regulatory approval from the FDA.
The global oligonucleotide synthesis market, based on application, is segmented into research, diagnostics, and therapeutics. The research segment accounted for the largest share in 2018. The higher emphasis on research activities by countries is expected to spur market growth during the forecast period. For instance, in Canada, there has been an increase in companies’ who are making significant expenses to expand their research and development domain. In both 2018 and 2021, the largest category of R&D spending was around US$1 million to US$5 million. In the field of research, oligonucleotides used for purposes such as gene knockout, genotyping, and diagnosis typically needs further purification after synthesis. Hence, the rise in research activities is expected to offer significant growth opportunities for the concerned market in the coming years.
End User-Based Insights
The global oligonucleotide synthesis market, based on end user, is segmented into academic research institutes, pharmaceutical & biotechnology companies, diagnostic laboratories, and other end users. The academic research institutes segment held the largest market share in 2018. The diagnostic laboratories are used for the development of new synthetic organisms based on altering the translation apparatus and developing modular nucleic acid software. The introduction of novel amino acids into proteins has the capability to base-pair and is performed using a variety of techniques, which includes directed evolution, computational design, and high-throughput synthesis. They have a gene synthesis facility capable of producing multiple kilobases of DNA every week. In parallel, DNA circuits based on strand exchange reactions and capable of executing embedded algorithms are being developed using tools such as aptamers and DNA nanotechnology. In October 2016, Eurofins MWG Operon LLC., a Eurofins Genomics company, launched the latest and advanced DNA sequencing Laboratory in Toronto, Ontario. The new sequencing facility offers fast, high-quality DNA sequencing services using the Sanger method to researchers in Canada.
The prominent/emerging players in the Oligonucleotide Synthesis Market research include:
- Thermo Fisher Scientific Inc.
- Molecular Assemblies
- Twist Biosciences
- DNA Script
- Nuclera Nucleics
- Camena Bioscience
- Ansa Biotechnologies
- Keasling Laboratories
Company overview provides the information about location of the company where it is headquartered along with the established year, employee strength as of 2017, regions where the company is operating and the key business areas.
Overall company/segment revenue for the year 2019, 2018, and 2017 is provided in the sub title “financial performance” (public listed companies) along with the analysis and explanation of the increase or decrease in the same due to factors such as mergers & acquisition, profit or loss in any strategic business unit (sbus) and others.
Product benchmarking comprises the comprehensive list of products pertaining to the respective market along with the application and key features.
Insights pertaining to the new product launch, strategic collaboration, mergers and acquisition, regulatory approval, and other developments by the company in market are covered under strategic initiatives section.
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